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ea0032p332 | Developmental Endocrinology | ECE2013

Crystal structure of the complex between an insulin-like peptide (DILP5) and an ILP binding protein (IMP-L2) from Drosophila melanogaster

Kulahin Nikolaj , Watson Christopher J , Sajid Waseem , Schluckebier Gerd , Andersen Asser S , Brzozowski Andrzej M , De Meyts Pierre

The insulin signalling system including the insulin receptor tyrosine kinase (IRTK) is evolutionarily ancient and appears in the first multicellular organisms (Cnidarians). The Drosophila melanogaster genome contains seven genes for insulin-like peptides (ILPs) that are expressed in neurosecretory cells in a highly tissue- and stage-specific pattern, DILP1-7. There is however only one IRTK (dIR). This system is important in the regulation of metabolism, growth, reprod...

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ea0035p337 | Developmental Endocrinology | ECE2014

Crystal structure of Drosophila imaginal morphogenesis protein-Late 2 (IMP-L2) in free form and bound to Drosophila insulin-like peptide 5 (DILP5) and human Insulin-like growth factor-I (hIGF1).

Kulahin Nikolaj , Watson Christopher J. , Sajid Waseem , Schluckebier Gerd , Kristensen Claus , Andersen Asser Sloth , Kristensen Ole , Norrman Matthias , Meyts Pierre De , Brzozowski Andrzej Marek

The insulin signalling system including the insulin receptor tyrosine kinase (IRTK) is evolutionarily ancient. The Drosophila Melanogaster genome contains seven genes for insulin-like peptides (ILPs) that are expressed in neurosecretory cells in a highly tissue- and stage-specific pattern, DILP17. There is however only one IRTK (dIR). This system is important in the regulation of metabolism, growth, reproduction and lifespan. We reported in 2011 the crystal stru...

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Endocrine Abstracts

Crystal structure of the complex between an insulin-like peptide (DILP5) and an ILP binding protein (IMP-L2) from Drosophila melanogaster

Crystal structure of Drosophila imaginal morphogenesis protein-Late 2 (IMP-L2) in free form and bound to Drosophila insulin-like peptide 5 (DILP5) and human Insulin-like growth factor-I (hIGF1).

BiosciAbstracts